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Gene Expression Profiling Identifies MMP-12 and ADAMDEC1 as Potential Pathogenic Mediators of Pulmonary Sarcoidosis

12 Feb 2009

Abstract excerpt

RATIONALE: Little is known about the genetic regulation of granulomatous inflammation in sarcoidosis. OBJECTIVES: To determine if tissue gene array analysis would identify novel genes engaged in inflammation and lung remodeling in patients with sarcoidosis. METHODS: Gene expression analysis was performed on tissues obtained from patients with sarcoidosis at the time of diagnosis (untreated) (n = 6) compared with...

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Share to Amyloidosis: Diagnosis, Treatment, Outcomes
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PMID: 19218196
DOI: 10.1164/rccm.200803-490oc

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