Article
Association of peroxisome proliferator-activated receptor-gamma gene polymorphisms with the development of asthma.
Respiratory medicine - 1 Jul 2009
Oh Sun-Hee, Park Se-Min, Lee Yoo Hoon, Cha Ji Yeon, Lee Ji-Yeon, Shin Eun Kyong, Park Jong-Sook, Park Byeong-Lae, Shin Hyoung Doo, Park Choon-Sik
Abstract excerpt
BACKGROUND: The peroxisome proliferator-activated receptors (PPAR) are the nuclear hormone receptor superfamily of ligand-activated transcriptional factors. PPAR-gamma (PPARG) activation downregulates production of Th2 type cytokines and eosinophil function. Additionally, treatment with a synthetic PPARG ligand can reduce lung inflammation and IFN-gamma, IL-4, and IL-2 production in experimental allergic asthma....
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