The P23T cataract mutation causes loss of solubility of folded gammaD-crystallin.

doi:10.1016/j.jmb.2004.08.050

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Article

The P23T cataract mutation causes loss of solubility of folded gammaD-crystallin.

Journal of molecular biology - 15 Oct 2004

Evans P, Wyatt K, Wistow G J, Bateman O A, Wallace B A, Slingsby C

Abstract excerpt

Mutations in the human gammaD-crystallin gene have been linked to several types of congenital cataracts. In particular, the Pro23 to Thr (P23T) mutation of human gammaD crystallin has been linked to cerulean, lamellar, coralliform, and fasciculiform congenital cataracts. We have expressed and purified wild-type human gammaD, P23T, and the Pro23 to Ser23 (P23S) mutant. Our measurements show that P23T is...

Topics

Amino Acid Sequence
Animals
Cataract
Circular Dichroism
Guanidine
Humans
Models, Molecular
Molecular Sequence Data
Mutation
Protein Denaturation
Protein Folding
Protein Structure, Secondary
Sequence Alignment
Solubility
gamma-Crystallins

Source

Open in PubMed

Identifiers

PMID: 15451671
DOI: 10.1016/j.jmb.2004.08.050

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