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Article

Relationship of injection drug use, antiretroviral therapy resistance, and genetic diversity in the HIV-1 pol gene.

Journal of acquired immune deficiency syndromes (1999) - 1 Apr 2009

Kowalski Jeanne, Gange Stephen J, Schneider Michael F, Tsai Hua-Ling, Templeton Alan, Shao Qiujia, Zhang Guang Wen, Yeh Mei-Fen, Young Mary, Markham Richard B

Abstract excerpt

OBJECTIVES: To determine if a history of injection drug use influences genotypic protease inhibitor (PI) resistance to antiretroviral agents. METHODS: We assessed the presence of resistance mutations in PI-naive injection drug users (IDUs) and non-IDUs participating in the Women's Interagency HIV Study. Eighteen HIV-infected participants who reported injection drug use before study enrollment and 32 HIV-infected...

Topics

Adult
Anti-HIV Agents
Drug Resistance, Viral
Female
Genes, pol
Genetic Variation
Genotype
HIV Infections
HIV-1
Humans
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Substance Abuse, Intravenous

Source

Open in PubMed Open full text

Identifiers

PMID: 19214121
DOI: 10.1097/QAI.0b013e318198a619
PMCID: PMC2937199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19214121-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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