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Article

G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction.

Endocrinology - 1 Jun 2009

Holst Birgitte, Egerod Kristoffer L, Jin Chunyu, Petersen Pia Steen, Østergaard Mette Viberg, Hald Jacob, Sprinkel A M Ejernaes, Størling Joachim, Mandrup-Poulsen Thomas, Holst Jens J, Thams Peter, Orskov Cathrine, Wierup Nils, Sundler Frank, Madsen Ole D, Schwartz Thue W

Abstract excerpt

G protein-coupled receptor (GPR)-39 is a seven-transmembrane receptor expressed mainly in endocrine and metabolic tissues that acts as a Zn(++) sensor signaling mainly through the G(q) and G(12/13) pathways. The expression of GPR39 is regulated by hepatocyte nuclear factor (HNF)-1alpha and HNF-4alpha, and in the present study, we addressed the importance of GPR39 for glucose homeostasis and pancreatic islets...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19213833
DOI: 10.1210/en.2008-1250
PMCID: PMC2732286

Genes

GPR39

Provenance

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