Article
New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.
Journal of medicinal chemistry - 12 Mar 2009
McCloskey Diane E, Bale Shridhar, Secrist John A, Tiwari Anita, Moss Thomas H, Valiyaveettil Jacob, Brooks Wesley H, Guida Wayne C, Pegg Anthony E, Ealick Steven E
Abstract excerpt
S-adenosylmethionine decarboxylase (AdoMetDC) is a critical enzyme in the polyamine biosynthetic pathway and depends on a pyruvoyl group for the decarboxylation process. The crystal structures of the enzyme with various inhibitors at the active site have shown that the adenine base of the ligands...
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