Article
Inferring disease-related pathways using a probabilistic epistasis model.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2009
Kanabar P N, Vaske C J, Yeang C H, Yildiz F H, Stuart J M
Abstract excerpt
MOTIVATION: We present a probabilistic model called a Joint Intervention Network (JIN) for inferring interactions among a chosen set of regulator genes. The input to the method are expression changes of downstream indicator genes observed under the knock-out of the regulators. JIN can use any num...
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