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Article

Association of DHODH haplotype variants and response to leflunomide treatment in rheumatoid arthritis.

Pharmacogenomics - 1 Sept 2012

O'Doherty Catherine, Schnabl Matthew, Spargo Llewellyn, Cleland Leslie G, James Michael, Proudman Susanna M, Wiese Michael D

Abstract excerpt

AIM: Leflunomide is a disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. Not all patients respond to leflunomide and, as it has potentially serious side effects, targeting only those most likely to benefit would address a clinical need. We aimed to determine whether variations in the gene encoding DHODH, the molecular target of leflunomide, might include biomarkers that could be...

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Source

Identifiers

PMID: 22966891
DOI: 10.2217/pgs.12.118

Genes

DHODH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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