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Article

Collaborative genome-wide association studies of diverse diseases: programs of the NHGRI's office of population genomics.

Pharmacogenomics - 1 Feb 2009

Manolio Teri A

Abstract excerpt

In the past 3 years, genome-wide association (GWA) studies have revolutionized the discovery of genetic variants associated with complex diseases. These studies present unique challenges in their conduct; particularly in the need for meticulous quality control of genotyping and for sample sizes large enough to withstand the severe penalty for multiple comparisons necessitated by testing hundreds of thousands of...

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PMID: 19207024
DOI: 10.2217/14622416.10.2.235
PMCID: PMC2714942

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