Article
Brain metabolism in Rett syndrome: age, clinical, and genotype correlations.
Annals of neurology - 1 Jan 2009
Horská Alena, Farage Luciano, Bibat Genila, Nagae Lídia M, Kaufmann Walter E, Barker Peter B, Naidu SakkuBai
Abstract excerpt
OBJECTIVE: Brain metabolism, as studied by magnetic resonance spectroscopy (MRS), has been previously shown to be abnormal in Rett syndrome (RTT). This study reports the relation of MRS findings to age, disease severity, and genotype. METHODS: Forty RTT girls (1-14 years old) and 12 age-matched control subjects were examined. Single-voxel proton MRS of left frontal white matter was performed. RESULTS: NAA/Cr...
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