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Article

Managing amyotrophic lateral sclerosis: slowing disease progression and improving patient quality of life.

Annals of neurology - 1 Jan 2009

Brooks Benjamin Rix

Abstract excerpt

It is now possible to slow the disease progression of amyotrophic lateral sclerosis (ALS), but documented improvement in the quality of life of ALS patients has been difficult to quantitate. Putative mechanisms involved in motor neuron degeneration in ALS include oxidative damage, mitochondrial dysfunction, neuroinflammation, growth factor deficiency, and glutamate excitotoxicity. Several pharmacological agents...

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PMID: 19191306
DOI: 10.1002/ana.21544

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SOD1

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