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Article

Cis-regulatory mutations in the Caenorhabditis elegans homeobox gene locus cog-1 affect neuronal development.

Genetics - 1 Apr 2009

O'Meara M Maggie, Bigelow Henry, Flibotte Stephane, Etchberger John F, Moerman Donald G, Hobert Oliver

Abstract excerpt

We apply here comparative genome hybridization as a novel tool to identify the molecular lesion in two Caenorhabditis elegans mutant strains that affect a neuronal cell fate decision. The phenotype of the mutant strains resembles those of the loss-of-function alleles of the cog-1 homeobox gene, an inducer of the fate of the gustatory neuron ASER. We find that both lesions map to the cis-regulatory control region...

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Identifiers

PMID: 19189954
DOI: 10.1534/genetics.108.097832
PMCID: PMC2666530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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