Article
What we know and what we would like to know about genetics and pulmonary arterial hypertension.
International journal of clinical practice. Supplement - 1 Mar 2009
Durrington H J, Morrell N W
Abstract excerpt
Research on the molecular basis of PAH caused by BMPR-II mutations is beginning to yield novel approaches to therapy, for example, small molecule inhibitors of ALK-5. Enhancement of BMP signalling may be possible with BMP-derived ligands or rescue of BMPR-II cell surface expression for some mutations. For mutations leading to nonsense mediated mRNA decay, approaches aimed at transcript stabilisation provide...
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