Article
Genetics and genomics of pulmonary arterial hypertension.
Journal of the American College of Cardiology - 30 Jun 2009
Machado Rajiv D, Eickelberg Oliver, Elliott C Gregory, Geraci Mark W, Hanaoka Masayuki, Loyd James E, Newman John H, Phillips John A, Soubrier Florent, Trembath Richard C, Chung Wendy K
Abstract excerpt
Pulmonary arterial hypertension (PAH) is a rare disorder that may be hereditable (HPAH), idiopathic (IPAH), or associated with either drug-toxin exposures or other medical conditions. Familial cases have long been recognized and are usually due to mutations in the bone morphogenetic protein receptor type 2 gene (BMPR2), or, much less commonly, 2 other members of the transforming growth factor-beta superfamily,...
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