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Article

Evaluation of MFRP as a candidate gene for high hyperopia.

Molecular vision - 1 Jan 2009

Wang Panfeng, Yang Zhikuan, Li Shiqiang, Xiao Xueshan, Guo Xiangming, Zhang Qingjiong

Abstract excerpt

PURPOSE: Mutations in the membrane-type frizzled-related protein (MFRP) gene have been identified in patients with pathologic high hyperopia associated with nanophthalmos or microphthalmia. This study is to test if a mutation in MFRP is responsible for physiologic high hyperopia. METHODS: DNA was prepared from venous leukocytes of 51 patients with physiologic high hyperopia (refraction of spherical equivalent >...

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Source

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Identifiers

PMID: 19169412
PMCID: PMC2629737

Genes

MFRP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evaluation of MFRP as a candidate gene for high hyperopia.PMID 19169412Read ↗

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Common MFRP sequence variants are not associated with moderate to high hyperopia, isolated microphthalmia, and high myopia.Semantic proximity Read ↗

MFRP variant results in nanophthalmos, retinitis pigmentosa, variability in foveal avascular zone.Semantic proximity Read ↗

Membrane frizzled-related protein gene-related ophthalmological syndrome: 30-month follow-up of a sporadic case and review of genotype-phenotype correlation in the literature.Semantic proximity Read ↗

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