Article
Histo-blood group gene polymorphisms as potential genetic modifiers of infection and cystic fibrosis lung disease severity.
PloS one - 1 Jan 2009
Taylor-Cousar Jennifer L, Zariwala Maimoona A, Burch Lauranell H, Pace Rhonda G, Drumm Mitchell L, Calloway Hollin, Fan Haiying, Weston Brent W, Wright Fred A, Knowles Michael R
Abstract excerpt
BACKGROUND: The pulmonary phenotype in cystic fibrosis (CF) is variable; thus, environmental and genetic factors likely contribute to clinical heterogeneity. We hypothesized that genetically determined ABO histo-blood group antigen (ABH) differences in glycosylation may lead to differences in microbial binding by airway mucus, and thus predispose to early lung infection and more severe lung disease in a subset of...
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