Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation

26 Jan 2009

Abstract excerpt

No abstract is available from the source.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Carcinogens and Genotoxicity Assessment
Share to DNA Repair Mechanisms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19169280
DOI: 10.1038/onc.2008.482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensationPMID 19169280Read ↗

Autophagy maintains stem cells and intestinal homeostasis in DrosophilaSemantic proximity Read ↗

Rack1 function in intestinal epithelia: regulating crypt cell proliferation and regeneration and promoting differentiation and apoptosis.Semantic proximity Read ↗

Chk2 and p53 Are Haploinsufficient with Dependent and Independent Functions to Eliminate Cells after Telomere LossSemantic proximity Read ↗

Wip1 Phosphatase Regulates p53-Dependent Apoptosis of Stem Cells and Tumorigenesis in the Mouse IntestineSemantic proximity Read ↗

Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis in miceSemantic proximity Read ↗

Telomere dysfunction and evolution of intestinal carcinoma in mice and humansSemantic proximity Read ↗

PIKfyve Deficiency Exacerbates Radiation-Induced Intestinal ToxicitySemantic proximity Read ↗

MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress.Semantic proximity Read ↗

Synergy between Prkdc and Trp53 regulates stem cell proliferation and GI-ARS after irradiation.Semantic proximity Read ↗

Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion.Semantic proximity Read ↗

Oncogenic KRAS and p53 Loss Drive Gastric Tumorigenesis in Mice That Can Be Attenuated by E-Cadherin ExpressionSemantic proximity Read ↗

Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.