Article
Overexpression of RhoE in Non-small Cell Lung Cancer (NSCLC) is associated with smoking and correlates with DNA copy number changes.
Cancer biology & therapy - 1 Mar 2007
Cuiyan Zhang, Jie Hang, Fang Zhou, Kezhi Zhang, Junting Wan, Susheng Shi, Xiaoli Feng, Ning Li, Xinhua Mu, Zhaoli Chen, Kang Shao, Bin Qiu, Baozhong Li, Sheng Chang, Meihua Xiong, Jie He
Abstract excerpt
RhoE, a small G protein, is constitutively GTP bound within the cell and can regulate actin cytoskeleton reorganization, leading to the appearance of aggregates of actin filaments. Although emerging evidence suggests that RhoE is causally involved in cancer formation and progression, little is known about its significance in solid cancer, including lung cancer. In the present study, the expression of RhoE was...
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