Article
Is there still a need for candidate gene approaches in the era of genome-wide association studies?
Genomics - 1 May 2009
Wilkening Stefan, Chen Bowang, Bermejo Justo Lorenzo, Canzian Federico
Abstract excerpt
Most genetic variants associated with complex diseases in humans are believed to have a small impact on risk. With traditional candidate gene/pathway approaches several associations with disease risk could be identified. However, now that genome-wide association studies are feasible, the question arises if there is still a need for these approaches. By using HapMap data, we evaluated to which extent commercially...
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