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Article

Genetics, environment, and gene-environment interactions in the development of systemic rheumatic diseases.

Rheumatic diseases clinics of North America - 1 Nov 2014

Sparks Jeffrey A, Costenbader Karen H

Abstract excerpt

Rheumatic diseases offer distinct challenges to researchers because of heterogeneity in disease phenotypes, low disease incidence, and geographic variation in genetic and environmental factors. Emerging research areas, including epigenetics, metabolomics, and the microbiome, may provide additional links between genetic and environmental risk factors in the pathogenesis of rheumatic disease. This article reviews...

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Identifiers

PMID: 25437282
DOI: 10.1016/j.rdc.2014.07.005
PMCID: PMC4250576

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