Article
Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif.
American journal of physiology. Renal physiology - 1 Apr 2009
Lichtnekert Julia, Vielhauer Volker, Zecher Daniel, Kulkarni Onkar P, Clauss Sebastian, Segerer Stephan, Hornung Veit, Mayadas Tanya N, Beutler Bruce, Akira Shizuo, Anders Hans-Joachim
Abstract excerpt
Viral RNA or bacterial products can activate glomerular mesangial cells via a subset of Toll-like receptors (Tlr). Because Tlr2-deficient mice were recently found to have attenuated nephrotoxic serum nephritis (NSN), we hypothesized that endogenous Tlr agonists can activate glomerular mesangial cells. Primary mesangial cells from C57BL/6 mice expressed Tlr1-6 and Tlr11 mRNA at considerable levels and produced...
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