Article
Age-related changes of transforming growth factor beta1 in Japanese children.
Allergology international : official journal of the Japanese Society of Allergology - 1 Mar 2009
Morimoto Masahiro, Matsui Eiko, Kawamoto Norio, Sakurai Satomi, Kaneko Hideo, Fukao Toshiyuki, Iwasa Shinichi, Shiraki Makoto, Kasahara Kimiko, Kondo Naomi
Abstract excerpt
BACKGROUND: Transforming growth factor beta1 (TGF beta 1) is an important factor in immunomodulation. The expression of TGF beta 1 has been shown to be influenced by the C-509T polymorphism in the TGF beta 1 gene. We investigated age-related changes of plasma TGF beta 1 levels in a birth-cohort study. In addition, the genotypes of the C-509T polymorphism were investigated in allergic and non-allergic subjects....
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