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Article

Differential human serum-mediated neutralization of PERV released from pig cells transfected with variants of hDAF.

Xenotransplantation - 1 Jan 2000

Okura Eiji, Ishimaru Aiko, Yamamoto Aki, Nakatsu Shino, Shirakura Ryota, Okabe Masaru, Sawa Yoshiki, Fukuzawa Masahiro, Okumura Meinoshin, Miyagawa Shuji

Abstract excerpt

BACKGROUND: Expression of complement regulatory proteins (CRP) on pig endothelial cells (PEC) is an effective means of avoiding induction of hyperacute rejection by human sera. However, pig endogenous retrovirus (PERV) from PEC transfected with CRP may acquire resistance to human sera. This study investigated a form of transfected CRP that is easily expressed on PERV particles. METHODS: The PEC line was...

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PMID: 19152664
DOI: 10.1111/j.1399-3089.2008.00496.x

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CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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