Article
Expression of the human alpha1,2-fucosyltransferase in transgenic pigs modifies the cell surface carbohydrate phenotype and confers resistance to human serum-mediated cytolysis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 1999
Costa C, Zhao L, Burton W V, Bondioli K R, Williams B L, Hoagland T A, Ditullio P A, Ebert K M, Fodor W L
Abstract excerpt
Hyperacute rejection (HAR) is the first critical immunological hurdle that must be addressed in order to develop xenogeneic organs for human transplantation. In the area of cell-based xenotransplant therapies, natural antibodies (XNA) and complement have also been considered barriers to successful engraftment. Transgenic expression of human complement inhibitors in donor cells and organs has significantly...
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