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Article

Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer.

Cancer letters - 8 May 2009

Zhang Bixiang, Halder Sunil K, Zhang Sanguo, Datta Pran K

Abstract excerpt

Despite a primary tumor suppressor role, there is compelling evidence suggesting that TGF-beta can promote tumor growth, invasion and metastasis in advanced stages of colorectal cancer. Blocking these tumor-promoting effects of TGF-beta provides a potentially important therapeutic strategy for the treatment of colorectal cancer. However, little is known about how the inhibitors of TGF-beta receptor kinases affect...

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Identifiers

PMID: 19147275
DOI: 10.1016/j.canlet.2008.11.035
PMCID: PMC2776056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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