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Article

FAS and FASLG polymorphisms and susceptibility to idiopathic azoospermia or severe oligozoospermia.

Reproductive biomedicine online - 1 Jan 2009

Wang Wei, Lu Ningxia, Xia Yankai, Gu Aihua, Wu Bin, Liang Jie, Zhang Wei, Wang Zengjun, Su Jiantang, Wang Xinru

Abstract excerpt

FAS, together with FASLG, triggers germ cell apoptosis, which occurs in various stages of mammalian testicular development. Single nucleotide polymorphisms (SNP) in the promoter regions of these two genes can influence their transcriptional activities and result in abnormal cell apoptosis, thus leading to spermatogenesis impairment. Therefore, it is reasonable to postulate that FAS and FASLG SNP may be associated...

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Source

Identifiers

PMID: 19146781
DOI: 10.1016/s1472-6483(10)60436-1

Genes

FASLG
FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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