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Article

Polymorphisms in cell death pathway genes are associated with altered sperm apoptosis and poor semen quality.

Human reproduction (Oxford, England) - 1 Oct 2009

Ji Guixiang, Gu Aihua, Hu Fan, Wang Shoulin, Liang Jie, Xia Yankai, Lu Chuncheng, Song Ling, Fu Guangbo, Wang Xinru

Abstract excerpt

BACKGROUND: The FAS/FASLG system has been proposed to play a key role in germ cell apoptosis. To elucidate the role of the genetic variants of cell death pathway genes in male infertility, we genotyped the polymorphisms of FAS, FASLG and caspase-8 (CASP8) genes and evaluated their effects on sperm apoptosis and semen quality in infertile men. METHODS: The genotypes of FAS, FASLG and CASP8 were determined in 620...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19542541
DOI: 10.1093/humrep/dep223

Genes

FAS
CASP8
FASLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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