Article
The negative prognostic impact of derivative 9 deletions in patients who received hydroxyurea treatment for chronic myelogenous leukemia in the chronic phase.
Onkologie - 1 Nov 2008
Li Jian-Yong, Xu Wei, Wu Wei, Zhu Yu, Qiu Hai-Rong, Zhang Run, Zhang Su-Jiang, Qian Si-Xuan
Abstract excerpt
BACKGROUND: Chronic myeloid leukemia (CML) is characterized by the formation of the BCR/ABL fusion gene, as a consequence of the Philadelphia (Ph) translocation between chromosomes 9 and 22. This study was to investigate the incidence and prognostic significance of derivative chromosome 9 (der(9)) deletions in CML patients who received hydroxyurea treatment in the chronic phase. PATIENTS AND METHODS: Fluorescence...
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