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Article

Familial multiple coagulation factor deficiencies: new biologic insight from rare genetic bleeding disorders.

Journal of thrombosis and haemostasis : JTH - 1 Sept 2004

Zhang B, Ginsburg D

Abstract excerpt

Combined deficiency of factor (F)V and FVIII (F5F8D) and combined deficiency of vitamin K-dependent clotting factors (VKCFD) comprise the vast majority of reported cases of familial multiple coagulation factor deficiencies. Recently, significant progress has been made in understanding the molecular mechanisms underlying these disorders. F5F8D is caused by mutations in two different genes (LMAN1 and MCFD2) that...

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Source

Identifiers

PMID: 15333032
DOI: 10.1111/j.1538-7836.2004.00857.x

Genes

LMAN1
MCFD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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