In <i>Bacillus subtilis</i> , the Sirtuin Protein Deacetylase, Encoded by the <i>srtN</i> Gene (Formerly <i>yhdZ</i> ), and Functions Encoded by the <i>acuABC</i> Genes Control the Activity of Acetyl Coenzyme A Synthetase

Abstract excerpt

This report provides in vivo evidence for the posttranslational control of the acetyl coenzyme A (Ac-CoA) synthetase (AcsA) enzyme of Bacillus subtilis by the acuA and acuC gene products. In addition, both in vivo and in vitro data presented support the conclusion that the yhdZ gene of B. subtilis encodes a NAD(+)-dependent protein deacetylase homologous to the yeast Sir2 protein (also known as sirtuin). On the...

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