Article
A SNAP25 promoter variant is associated with early-onset bipolar disorder and a high expression level in brain.
Molecular psychiatry - 1 Jul 2010
Etain B, Dumaine A, Mathieu F, Chevalier F, Henry C, Kahn J-P, Deshommes J, Bellivier F, Leboyer M, Jamain S
Abstract excerpt
Bipolar disorder (BD) is one of the most common and persistent psychiatric disorders. Early-onset BD has been shown to be the most severe and familial form. We recently carried out a whole-genome linkage analysis on sibpairs affected by early-onset BD and showed that the 20p12 region was more frequently shared in our families than expected by chance. The synaptosomal-associated protein SNAP25 is a presynaptic...
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