Article
HLA class I supertypes in type 1 diabetic children in an urban children's hospital.
Annals of the New York Academy of Sciences - 1 Dec 2008
Antal Zoltan, Jarchum Irene, DiLorenzo Teresa P
Abstract excerpt
Type 1 diabetes is an autoimmune disorder characterized by progressive destruction of insulin-secreting beta cells of the pancreas, in which CD8(+) T cells play a critical role. The diversity in the HLA alleles expressed among various racial and ethnic groups leads to great variability in antigen presentation and recognition by CD8(+) T cells in the context of MHC class I molecules. To date, studies aimed at...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.