Relationship among Oxidative Stress, DNA Damage, and Proliferative Capacity in Human Corneal Endothelium

Abstract excerpt

PURPOSE: To determine whether human corneal endothelial cells (HCECs) exhibit signs of oxidative DNA damage and to test whether oxidative stress affects the proliferative capacity of HCECs. METHODS: Donor human corneas were divided into two age groups: young (<30 years) and older (>50 years). An 8-hydroxy-2'-deoxyguanosine (8-OHdG) ELISA assay was used to quantify oxidative DNA damage in HCECs freshly isolated...

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