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Article

Age-Related Gene Response of Human Corneal Endothelium to Oxidative Stress and DNA Damage

19 Nov 2010

Abstract excerpt

PURPOSE: Nuclear oxidative DNA damage increases with age in human corneal endothelial cells (HCECs) and contributes to their decreased proliferative capacity. These studies investigated whether HCECs respond to this damage by upregulating their expression of oxidative stress and DNA damage-signaling genes in an age-dependent manner. METHODS: HCECs were dissected from the corneas of young (30 years and younger)...

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Identifiers

PMID: 21087955
DOI: 10.1167/iovs.10-6492

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