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Article

The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast.

Molecular biology of the cell - 1 Feb 2009

Tully Gregory H, Nishihama Ryuichi, Pringle John R, Morgan David O

Abstract excerpt

The anaphase-promoting complex (APC) is a ubiquitin ligase that controls progression through mitosis by targeting specific proteins for degradation. It is unclear whether the APC also contributes to the control of cytokinesis, the process that divides the cell after mitosis. We addressed this question in the yeast Saccharomyces cerevisiae by studying the effects of APC mutations on the actomyosin ring, a...

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Source

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Identifiers

PMID: 19109423
DOI: 10.1091/mbc.e08-08-0822
PMCID: PMC2642741

Genes

APC
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast.PMID 19109423Read ↗

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Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis.Semantic proximity Read ↗

Rng2p, a protein required for cytokinesis in fission yeast, is a component of the actomyosin ring and the spindle pole body.Semantic proximity Read ↗

Cytokinetic actomyosin ring formation and septation in fission yeast are dependent on the full recruitment of the polo-like kinase Plo1 to the spindle pole body and a functional spindle assembly checkpoint.Semantic proximity Read ↗

Saccharomyces cerevisiae Mob1p is required for cytokinesis and mitotic exit.Semantic proximity Read ↗

Direct evidence for a critical role of myosin II in budding yeast cytokinesis and the evolvability of new cytokinetic mechanisms in the absence of myosin II.Semantic proximity Read ↗

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