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Article

Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH.

Hepatology (Baltimore, Md.) - 1 Feb 2009

Musso Giovanni, Gambino Roberto, Pacini Giovanni, Pagano Gianfranco, Durazzo Marilena, Cassader Maurizio

Abstract excerpt

UNLABELLED: Genetic factors underlying the association of NAFLD with diabetes and atherosclerosis are unknown. Recent human studies suggest transcription factor 7-like 2 (TCF7L2) polymorphism predisposes to diabetes through modulation of beta-cell function and modulates lipid levels in familial d...

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Identifiers

PMID: 19105201
DOI: 10.1002/hep.22659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19105201-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH.PMID 19105201Read ↗

rs7903146 (C/T) polymorphism of Transcription factor 7 like 2 (TCF7L-2) gene is independently associated with non-alcoholic fatty liver disease in Asian Indians.Semantic proximity Read ↗

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Expression of the transcription factor 7-like 2 gene (TCF7L2) in human adipocytes is down regulated by insulin.Semantic proximity Read ↗

TM6SF2 rs58542926 variant affects postprandial lipoprotein metabolism and glucose homeostasis in NAFLD.Semantic proximity Read ↗

TA allele of rs2070673 in the CYP2E1 gene is associated with lobular inflammation and nonalcoholic steatohepatitis in patients with biopsy-proven nonalcoholic fatty liver disease.Semantic proximity Read ↗

Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.Semantic proximity Read ↗

Impact of sterol regulatory element-binding factor-1c polymorphism on incidence of nonalcoholic fatty liver disease and on the severity of liver disease and of glucose and lipid dysmetabolism.Semantic proximity Read ↗

Transcription factor 7-like 2 single nucleotide polymorphisms are associated with lipid profile in the Balinese.Semantic proximity Read ↗

Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.Semantic proximity Read ↗

Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolismSemantic proximity Read ↗

TCF7L2 plays a complex role in human adipose progenitor biology which may contribute to genetic susceptibility to type 2 diabetesSemantic proximity Read ↗

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