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Article

Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH.

Hepatology (Baltimore, Md.) - 1 Feb 2009

Musso Giovanni, Gambino Roberto, Pacini Giovanni, Pagano Gianfranco, Durazzo Marilena, Cassader Maurizio

Abstract excerpt

UNLABELLED: Genetic factors underlying the association of NAFLD with diabetes and atherosclerosis are unknown. Recent human studies suggest transcription factor 7-like 2 (TCF7L2) polymorphism predisposes to diabetes through modulation of beta-cell function and modulates lipid levels in familial dyslipidemia. Emerging experimental evidence connects TCF7L2 to adipocyte metabolism and lipid homeostasis, as well. We...

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Identifiers

PMID: 19105201
DOI: 10.1002/hep.22659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH.PMID 19105201Read ↗

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