Article
Pleiotropic effects in Eya3 knockout mice.
BMC developmental biology - 22 Dec 2008
Söker Torben, Dalke Claudia, Puk Oliver, Floss Thomas, Becker Lore, Bolle Ines, Favor Jack, Hans Wolfgang, Hölter Sabine M, Horsch Marion, Kallnik Magdalena, Kling Eva, Moerth Corinna, Schrewe Anja, Stigloher Christian, Topp Stefanie, Gailus-Durner Valerie, Naton Beatrix, Beckers Johannes, Fuchs Helmut, Ivandic Boris, Klopstock Thomas, Schulz Holger, Wolf Eckhard, Wurst Wolfgang, Bally-Cuif Laure, de Angelis Martin Hrabé, Graw Jochen
Abstract excerpt
BACKGROUND: In Drosophila, mutations in the gene eyes absent (eya) lead to severe defects in eye development. The functions of its mammalian orthologs Eya1-4 are only partially understood and no mouse model exists for Eya3. Therefore, we characterized the phenotype of a new Eya3 knockout mouse mutant. RESULTS: Expression analysis of Eya3 by in-situ hybridizations and beta-Gal-staining of Eya3 mutant mice revealed...
Topics
- Animals
- Base Sequence
- DNA
- DNA-Binding Proteins
- Eye
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Developmental
- Homozygote