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Article

Mutagenesis of the Dengue Virus Type 2 NS5 Methyltransferase Domain

10 May 2008

Abstract excerpt

The Flavivirus NS5 protein possesses both (guanine-N7)-methyltransferase and nucleoside-2'-O methyltransferase activities required for sequential methylation of the cap structure present at the 5' end of the Flavivirus RNA genome. Seventeen mutations were introduced into the dengue virus type 2 NS5 methyltransferase domain, targeting amino acids either predicted to be directly involved in S-adenosyl-l-methionine...

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PMID: 18469001
DOI: 10.1074/jbc.m800613200

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