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Article

Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid.

Proteomics. Clinical applications - 1 Apr 2011

Perluigi Marzia, di Domenico Fabio, Fiorini Ada, Cocciolo Annalisa, Giorgi Alessandra, Foppoli Cesira, Butterfield D Allan, Giorlandino Maurizio, Giorlandino Claudio, Schininà M Eugenia, Coccia Raffaella

Abstract excerpt

PURPOSE: The present study aims to evaluate a set of oxidative stress biomarkers in the amniotic fluid (AF) of women carrying Down syndrome (DS) fetuses that could prove in vivo the early occurrence of oxidative damage in DS. EXPERIMENTAL DESIGN: To assess the extent of protein oxidation in DS AF, we measured protein carbonylation and protein-bound HNE by slot-blot analysis, total and oxidized GSH levels by...

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PMID: 21360684
DOI: 10.1002/prca.201000121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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