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Article

Preventing Bacterial Infections with Pilus-Based Vaccines: the Group B Streptococcus Paradigm

16 Dec 2008

Abstract excerpt

We recently described the presence of 3 pilus variants in the human pathogen group B streptococcus (GBS; also known as Streptococcus agalactiae), each encoded by a distinct pathogenicity island, as well as the ability of pilus components to elicit protection in mice against homologous challenge. To determine whether a vaccine containing a combination of proteins from the 3 pilus types could provide broad...

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PMID: 19086816
DOI: 10.1086/595564

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