Multistate, Population-Based Distributions of Candidate Vaccine Targets, Clonal Complexes, and Resistance Features of Invasive Group B Streptococci Within the United States, 2015-2017.

doi:10.1093/cid/ciaa151

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Article

Multistate, Population-Based Distributions of Candidate Vaccine Targets, Clonal Complexes, and Resistance Features of Invasive Group B Streptococci Within the United States, 2015-2017.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Mar 2021

McGee Lesley, Chochua Sopio, Li Zhongya, Mathis Saundra, Rivers Joy, Metcalf Benjamin, Ryan Alison, Alden Nisha, Farley Monica M, Harrison Lee H, Snippes Vagnone Paula, Lynfield Ruth, Smelser Chad, Muse Alison, Thomas Ann R, Schrag Stephanie, Beall Bernard W

Abstract excerpt

BACKGROUND: Group B Streptococcus (GBS) is a leading cause of neonatal sepsis and meningitis and an important cause of invasive infections in pregnant and nonpregnant adults. Vaccines targeting capsule polysaccharides and common proteins are under development. METHODS: Using whole genome sequencing, a validated bioinformatics pipeline, and targeted antimicrobial susceptibility testing, we characterized 6340...

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PMID: 32060499
DOI: 10.1093/cid/ciaa151
PMCID: PMC8071603

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