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Distribution of pilus islands of group B streptococcus associated with maternal colonization and invasive disease in South Africa

13 Oct 2012

Abstract excerpt

Group B streptococcus (GBS) is a leading cause of neonatal sepsis. Sortase-dependent pilus-like structures have been identified on the surface of GBS, and have been found to be important in the adhesion and attachment of GBS to host cells. Three pilus island alleles, PI-1, PI-2a and PI-2b, have been described, and their proteins are being explored as vaccine candidates. The pilus islands from 541 colonization...

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PMID: 23065545
DOI: 10.1099/jmm.0.052951-0

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