Article
Selection of unrelated donors for bone marrow transplantation is improved by HLA class II genotyping with oligonucleotide hybridization.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1991
Tiercy J M, Morel C, Freidel A C, Zwahlen F, Gebuhrer L, Bétuel H, Jeannet M, Mach B
Abstract excerpt
As the demand for donors for bone marrow transplantation increases, the use of HLA-matched, genetically unrelated donors represents a promising strategy. It is well documented that the clinical outcome of bone marrow transplantation is directly dependent on optimal matching for HLA class I and class II specificities. Molecular studies have revealed the existence of a much larger number of HLA class II alleles...
Topics
- Bone Marrow Transplantation
- DNA Replication
- Genes, MHC Class II
- Genotype
- HLA-D Antigens
- HLA-DQ Antigens
- HLA-DR Antigens
- Histocompatibility Testing
- Humans
- Lymphocytes