Article
Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.
Molecular psychiatry - 1 Feb 2010
Craddock N, Jones L, Jones I R, Kirov G, Green E K, Grozeva D, Moskvina V, Nikolov I, Hamshere M L, Vukcevic D, Caesar S, Gordon-Smith K, Fraser C, Russell E, Norton N, Breen G, St Clair D, Collier D A, Young A H, Ferrier I N, Farmer A, McGuffin P, Holmans P A, Donnelly P, Owen M J, O'Donovan M C
Abstract excerpt
Despite compelling evidence for a major genetic contribution to risk of bipolar mood disorder, conclusive evidence implicating specific genes or pathophysiological systems has proved elusive. In part this is likely to be related to the unknown validity of current phenotype definitions and consequent aetiological heterogeneity of samples. In the recent Wellcome Trust Case Control Consortium genome-wide association...
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