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[Cell engineering and genetic approaches to the development of models of human embryonic stem cells for studying genetic disorders].

Biofizika - 1 Jan 2000

Galat V, Ozen R, Verlinskiĭ Iu, Greiss Hisham, Krotova E, Mazepa A, Chaĭlakhian L M, Iannaccone P

Abstract excerpt

A novel approach to the establishment of genetically modified human embryonic stem cell (hESC) lines has been developed, and it has been shown that mutant hESC may be derived from affected embryos after preimplantation genetic diagnosis screening for a particular single gene disorder. Here we provide the description of embryo and cell manipulation procedures, diagnostic lay out, analysis of the efficiency of...

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Identifiers

PMID: 20586327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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