Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways.

Cold Spring Harbor perspectives in medicine - 1 Sept 2012

Cookson Mark R

Abstract excerpt

Three genes have been identified that cause, in humans, autosomally inherited parkinsonism. These are PARK2, encoding the E3 ubiquitin ligase parkin; PINK1, a mitochondrial kinase; and PARK7, which codes for the protein DJ-1. In several experimental systems, it has been shown that all three proteins impact mitochondrial function and/or oxidative stress responses. These are probably related because mitochondria...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Intracellular Signaling Peptides and Proteins
Share to Oncogene Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oxidative Stress

Share to Parkinson Disease

Share to Parkinsonian Disorders

Share to Protein Deglycase DJ-1

Share to Protein Kinases

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 22951446
DOI: 10.1101/cshperspect.a009415
PMCID: PMC3426824

Genes

PINK1
PARK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways.PMID 22951446Read ↗

DJ-1, PINK1, and their effects on mitochondrial pathways.Semantic proximity Read ↗

Parkin and PINK1 functions in oxidative stress and neurodegeneration.Semantic proximity Read ↗

Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's diseaseSemantic proximity Read ↗

Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes.Semantic proximity Read ↗

[Parkin and mitochondria].Semantic proximity Read ↗

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesisSemantic proximity Read ↗

Parkinson's disease: insights from pathways.Semantic proximity Read ↗

Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonismSemantic proximity Read ↗

Mitochondrial Dysfunction and Oxidative Stress in Parkinson’s DiseaseSemantic proximity Read ↗

Mitochondrial dysfunction and oxidative stress in Parkinson’s disease: mechanisms, biomarkers, and therapeutic strategiesSemantic proximity Read ↗

Emerging pathways in genetic Parkinson's disease: autosomal-recessive genes in Parkinson's disease--a common pathway?Semantic proximity Read ↗

Mitochondria and dopamine: new insights into recessive parkinsonism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.