Article
A mutant collagen XIII alters intestinal expression of immune response genes and predisposes transgenic mice to develop B-cell lymphomas.
Cancer research - 15 Dec 2008
Tuomisto Anne, Sund Malin, Tahkola Jenni, Latvanlehto Anne, Savolainen Eeva-Riitta, Autio-Harmainen Helena, Liakka Annikki, Sormunen Raija, Vuoristo Jussi, West Anne, Lahesmaa Riitta, Morse Herbert C, Pihlajaniemi Taina
Abstract excerpt
Epithelial cells of mucosal surfaces are critical for maintaining immune homeostasis by aiding in the discrimination of pathogenic and commensal microorganisms and modulating the activities of antigen-presenting cells and lymphocytes. Functional breakdowns resulting in chronic infection and inflammation are associated with the development of hematologic and solid neoplasms for which detailed pathogenetic...
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