Article
The subcutaneous inoculation of pH 6 antigen mutants of Yersinia pestis does not affect virulence and immune response in mice.
Journal of medical microbiology - 1 Jan 2009
Anisimov Andrey P, Bakhteeva Irina V, Panfertsev Evgeniy A, Svetoch Tat'yana E, Kravchenko Tat'yana B, Platonov Mikhail E, Titareva Galina M, Kombarova Tat'yana I, Ivanov Sergey A, Rakin Alexander V, Amoako Kingsley K, Dentovskaya Svetlana V
Abstract excerpt
Two isogenic sets of Yersinia pestis strains were generated, composed of wild-type strains 231 and I-1996, their non-polar pH 6(-) mutants with deletions in the psaA gene that codes for its structural subunit or the whole operon, as well as strains with restored ability for temperature- and pH-dependent synthesis of adhesion pili or constitutive production of pH 6 antigen. The mutants were generated by...
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