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Article

Leader-induced phosphorylation of nucleoporins correlates with nuclear trafficking inhibition by cardioviruses.

Journal of virology - 1 Feb 2009

Porter Frederick W, Palmenberg Ann C

Abstract excerpt

Picornaviruses disrupt nucleocytoplasmic trafficking pathways during infection. Poliovirus and rhinovirus inhibit nuclear protein import/export through a series of 2A protease-dependent cleavages within nuclear pore proteins (nucleoporins [Nups]), including Nup62, Nup98, and Nup153. Cardioviruses lack the same protease and instead affect trafficking inhibition through an activity mapped to their leader (L)...

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Identifiers

PMID: 19073724
DOI: 10.1128/JVI.01752-08
PMCID: PMC2643766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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