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Article

Design of a highly potent HIV-1 fusion inhibitor targeting the gp41 pocket.

AIDS (London, England) - 2 Jan 2015

Chong Huihui, Qiu Zonglin, Su Yang, Yang Lingli, He Yuxian

Abstract excerpt

OBJECTIVE: T20 (Enfuvirtide), which is a 36-residue peptide derived from the C-terminal heptad repeat (CHR) of gp41, is the only clinically available HIV-1 fusion inhibitor, but it easily induces drug resistance, which calls for next-generation drugs. DESIGN: We recently demonstrated that the M-T hook structure can be used to design a short CHR peptide that specifically targets the conserved gp41 pocket rather...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25562490
DOI: 10.1097/QAD.0000000000000498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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